What diseases can cause high uric acid?
In recent years, with the improvement of living standards and changes in dietary structure, hyperuricemia has become a health problem that more and more people pay attention to. High uric acid not only causes gout, but may also induce a variety of diseases. This article will combine the hot topics and hot content on the Internet in the past 10 days to analyze in detail the dangers of high uric acid and related diseases.
1. Definition and harm of high uric acid
Uric acid is the end product of purine metabolism in the human body and is normally excreted through urine. But when uric acid is produced too much or its excretion is reduced, the concentration of uric acid in the blood will increase, forming hyperuricemia. Long-term high uric acid can cause damage to multiple systems in the body.
| Uric acid level (μmol/L) | health risks |
|---|---|
| Men＞420, women＞360 | hyperuricemia |
| Long term＞540 | Significantly increased risk of gout |
| Long term＞600 | High risk of kidney damage |
2. Diseases that may be caused by high uric acid
1.Gout
Gout is the most common complication of high uric acid. When uric acid crystals are deposited in the joints, it can cause acute arthritis, which is characterized by redness, swelling, and severe pain in the joints. It is common in the big toe, ankle joints, etc.
| Gout staging | Symptoms |
|---|---|
| Asymptomatic hyperuricemia stage | No clinical symptoms |
| acute gouty arthritis | Sudden joint redness, swelling, heat and pain |
| Intermission | Asymptomatic |
| chronic tophi gout | Joint deformity, tophi formation |
2.kidney disease
Uric acid crystals can be deposited in the kidneys, causing a variety of kidney diseases:
3.cardiovascular disease
Studies have shown that hyperuricemia is associated with a variety of cardiovascular diseases:
| cardiovascular disease | Correlation with high uric acid |
|---|---|
| high blood pressure | For every 1 mg/dl increase in uric acid, the risk of hypertension increases by 13% |
| coronary heart disease | People with high uric acid have 1.5 times increased risk of coronary heart disease |
| heart failure | Uric acid levels correlate with heart failure severity |
4.metabolic syndrome
Hyperuricemia often coexists with metabolic abnormalities such as obesity, insulin resistance, and hyperlipidemia, which increases the risk of type 2 diabetes.
5.neurological disease
Recent studies have found that high uric acid may be related to the following neurological diseases:
3. How to prevent and treat diseases related to high uric acid
1.Diet control
| food category | Suggestions |
|---|---|
| High purine foods | Limit intake (e.g. offal, seafood) |
| Medium purine foods | Moderate intake |
| low purine foods | Encourage eating more (e.g. vegetables, fruits) |
| drinks | Drink more water and limit alcohol and sugary drinks |
2.lifestyle adjustments
3.drug treatment
Under the guidance of a doctor, the following drugs may be considered:
| drug type | Mechanism of action |
|---|---|
| Drugs that inhibit uric acid production | Such as allopurinol, febuxostat |
| Drugs that promote uric acid excretion | benzbromarone |
| Alkalizing urine medications | such as sodium bicarbonate |
4. Latest research progress
According to the medical research hot spots in the past 10 days:
Conclusion
High uric acid not only causes gout but may also lead to a variety of serious diseases. Through regular testing of uric acid levels, lifestyle adjustments and reasonable treatment, the occurrence and development of related diseases can be effectively prevented and controlled. It is recommended that high-risk groups test uric acid every 3-6 months for early detection and early intervention.
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